Current vaccines target regions of the virus that are highly variable. These vaccines need to be updated regularly and administered each year. Vaccines in development target conserved regions to avoid the need for regular updates.

 

However, these vaccine concepts produce a poor protective immune response that is also difficult to maintain. Our vaccine overcomes such issues by targeting regions of the virus, which are highly protective and easy to induce an immune response against as well as limited in variability, thereby inducing protection which can be easily maintained.

References:

 

CDC Foundation, Flu Costs The U.S. More Than $87 Billion Annually. 2014. Available at: https://www.cdcfoundation.org/pr/flu-costs-United-States-87-billion-annually

WOrld Health Organisation 2009. Influenza WHO fact sheet no. 211. Available at: http://www.who.int/mediacentre/factsheets/fs211/en/.

Paules, C. & Subbarao, K., 2017. Influenza. The Lancet, 390(10095), pp.697–708.

Recker, M. et al., 2007. The generation of influenza outbreaks by a network of host immune responses against a limited set of antigenic types. Proceedings of the National Academy of Sciences, 104(18), pp.7711–7716. Available at: http://www.pnas.org/cgi/doi/10.1073/pnas.0702154104.

Thompson, C.P. et al., 2018. A naturally protective epitope of limited variability as an influenza vaccine target. Nature Communications, (9), p.3859. Available at: http://dx.doi.org/10.1038/s41467-018-06228-8.

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