Media Coverage:

A flu vaccine you get once, not once a year? A new company in Cincinnati's working on one
By Anne Saker, Cincinnati Enquirer - Sept. 12, 2019

 

Blue Water Vaccines, a Greater Cincinnati startup, has received $7 million in financing to commercialize a single vaccine that could offer protection against all types of flu.

The seed round was led by CincyTech, the Uptown venture capital enterprise that provides funding and entrepreneurial support to help transform innovation into digital and health-focused companies.

The round was oversubscribed, so private investors affiliated with CincyTech also participated.

The payoff could be enormous. Globally, an estimated 1 billion cases of flu every year result in up to 650,000 deaths. Read more: CincinnatiEnquirer.pdf

Cincinnati startup lands $7M in financing to develop universal flu vaccine

By Barrett J. Brunsman, Cincinnati Business Courier - July 24, 2019

 

 

 

 

 

 

 

 

 

Another flu season approaches in North America, and Americans are getting the nudge for a flu shot, crossing their fingers for a good match against the virus. But a new local company believes it will soon produce a better weapon against flu – a universal vaccine that will last a lifetime. “Our goal is to change the world,” said Joseph Hernandez, chief executive officer of Blue Water Vaccines. Human testing on the company’s universal vaccine is planned within 18 to 24 months, he said, "then we’ll know if we truly have the revolution on our hands.” If the vision comes to pass, the cool-weather ritual of the annual flu shot will end, Hernandez said, perhaps as soon as five years from now. Read more here

Major Scientific Studies:

A Naturally Protective Epitope of Limited Variability as an Influenza Vaccine Target (ELV_H1N1_paper.pdf) outlines the H1N1 influenza A vaccine target that we have identified. We've identified similar targets in the other influenza strains circulating in humans - H3N2 influenza A and also influenza B. 

The Generation of Influenza Outbreaks by a Network of Host Immune Responses Against a Limited Set of Antigenic Types (math_model.pdf) outlines the mathematical framework that the Oxford group has developed over the past 20 years. This framework helped us to predict the existence of the influenza vaccine targets that we are including in our vaccine and acts as the theoretical basis for our work.
 

Written Reports:

Pre-clinical success for a universal flu vaccine offers hope for new third generation approach - Development of a vaccine candidate with potential to save millions worldwide will be accelerated in commercialisation deal with Blue Water Vaccines.

Biology News, University of Oxford, Issue Eight | 2019, p.4

Scientists are racing to create a flu vaccine that protects everyone

Wired, 24/11/18, Matt Reynolds

https://www.wired.co.uk/article/universal-flu-vaccine-berg

 

Flu vaccine breakthrough raises hopes for lifelong protection i (The paper for today),

22/09/2018, p.5, Tom Bawden

https://inews.co.uk/news/health/why-a-universal-flu-vaccine-could-be-available-within-a-matter-of-years/

 

Boost for New Vaccine to End Annual Flu Jabs
The Daily Mirror, 22/09/2018, p.7, Roger Dobson

https://www.mirror.co.uk/lifestyle/health/breakthrough-long-term-flu-vaccine-12973708

 

Flu Jab ‘To Last a Lifetime’

Daily Express, 22/09/2018, p.31, Roger Dobson

https://www.dailymail.co.uk/health/article-5983801/Could-new-jab-stop-strains-flu-UK-researchers-working-universal-vaccine.html

 

New Study Offers Hope of Universal Flu Vaccine
Xinhua News Agency online, 21/09/2018

http://www.xinhuanet.com/english/2018-09/22/c_137484946.htm *

 

Oxford University Press Report

http://www.ox.ac.uk/news/2018-09-21-pre-clinical-success-universal-flu-vaccine-offers-hope-new-third-generation-approach

 

New Study Offers Hope of Universal Flu Vaccine

Xinhua, 21 Sep 2018

http://www.xinhuanet.com/english/2018-09/22/c_137484946.htm

 

Vaccino universale contro influenza e HIV sempre più vicino: ottenuti i primi risultati

Fanpage, 24 Sep 2018

https://scienze.fanpage.it/vaccino-universale-contro-influenza-e-hiv-sempre-piu-vicino-ottenuti-i-primi-risultati/

 

Finding Influenza’s Achilles’ Heel

Virology Research Services, 5 Nov 2018

http://virologyresearchservices.com/2018/10/05/finding-influenzas-achilles-heel/

 

La vacuna universal para la gripe está cerca, pero mientras tanto... ¡no olvide su inyección!

El Confidencial, 24 Oct 2018

https://www.elconfidencial.com/tecnologia/ciencia/2018-10-24/gripe-vacuna-universal-europa_1634415/

 

Британские биологи нащупали "ахиллесову пяту" вируса гриппа

РИА Новости, 21 Sep 2018

https://ria.ru/science/20180921/1529078751.html 

 

New Study Offers Hope of Universal Flu Vaccine

China.org, 21 Sep 2018

http://www.china.org.cn/world/Off_the_Wire/2018-09/22/content_63772461.htm

 

Askel kohti elinikäistä influenssarokotetta – Tutkimuksen johtaja: ”Voi olla vallankumous”

Suomen Kuvalehti, 27 Sep 2018

https://suomenkuvalehti.fi/jutut/tiede/askel-kohti-elinikaista-influenssarokotetta-tutkimuksen-johtaja-voi-olla-vallankumous/

 

Pre-clinical Success Offers Hope for Universal Flu Vaccine

Technology Networks, 24 Sep 2018

https://www.technologynetworks.com/biopharma/news/pre-clinical-success-offers-hope-for-universal-flu-vaccine-309860

 

Pre-Clinical Success for a Universal Flu Vaccine Offers Hope for Third Generation Approach

Drug Discovery and Development , 21 Sep 2018

https://www.rdmag.com/news/2018/09/pre-clinical-success-universal-flu-vaccine-offers-hope-third-generation-approach

 

Pre-Clinical Success for a Universal Flu Vaccine Offers Hope for Third Generation Approach

R&D, 21 Sep 2018

https://www.rdmag.com/news/2018/09/pre-clinical-success-universal-flu-vaccine-offers-hope-third-generation-approach

 

Pre-Clinical Success for Universal Flu Vaccine Offers Hope

Health Canal, 21 Sep 2018

https://www.healthcanal.com/infections/flu/246416-pre-clinical-success-for-universal-flu-vaccine-offers-hope.html

 

Pre-Clinical Success for Universal Flu Vaccine Offers Hope

Environmental News Network, 21 Sep 2018

https://www.enn.com/articles/55535-pre-clinical-success-for-universal-flu-vaccine-offers-hope

 

Researchers Demonstrate Pre-Clinical Success for Universal Flu Vaccine in New Paper

The Medical News, 21 Sep 2018

https://www.news-medical.net/news/20180921/Researchers-demonstrate-pre-clinical-success-for-universal-flu-vaccine-in-new-paper.aspx

 

Pre-Clinical Success for a Universal Flu Vaccine Offers Hope for Third Generation Approach

Science Daily, 21 Sep 2018

https://www.sciencedaily.com/releases/2018/09/180921082943.htm

 

Pre-Clinical Success for a Universal Flu Vaccine Offers Hope for Third Generation Approach

MedicalXpress, 21 Sep 2018

https://medicalxpress.com/news/2018-09-pre-clinical-success-universal-flu-vaccine.html

 

Pre-Clinical Success for a Universal Flu Vaccine Offers Hope for Third Generation Approach

https://www.eurekalert.org/pub_releases/2018-09/uoo-psf092018.php

 

Pre-Clinical Success for a Universal Flu Vaccine Offers Hope for Third Generation Approach

World Pharma News, 21 September 2018

http://www.worldpharmanews.com/research/4547-pre-clinical-success-for-a-universal-flu-vaccine-offers-hope-for-third-generation-approach


Radio:

Radio: BBC Radio Oxford, Lilley Mitchell

25/09/2018, 15:00

Researchers have found an approach that can lead to a novel type of universal flu vaccine, according to a study released on Friday by the University of Oxford. A team from the University, based on mathematical models, theorized that parts of the virus targeted by the immune system are, in fact, limited in variability and act as constraints on the evolution of the virus.

The results of these studies can be exploited to create a novel type of universal or broadly protective influenza vaccine, which once administered would provide lifelong protection against influenza.


Radio: BBC Radio Oxford, Howard Bentham

25/09/2018, 16:33

Lecture:

Modelling Infectious Disease Dynamics for Global Health - Using Multi-Focus Models of Pathogen Evolution to Design Vaccines

CMMID Inaugural Annual Lecture, 28/03/2019, Prof. Sunetra Gupta

https://panopto.lshtm.ac.uk/Panopto/Pages/Viewer.aspx?id=f53e4f03-4814-4faa-94dc-38f37f3aaca4

Blogs:

From a Mathematical Model to a New Influenza Vaccine

Nature Microbiology Community, 21 Sep 2018

https://naturemicrobiologycommunity.nature.com/users/175433-sunetra-gupta/posts/38978-from-a-mathematical-model-to-a-new-influenza-vaccine

 

Учёные из Британии нашли ахиллесову пяту вируса гриппа

«Life.ru» — информационный портал, 21 Sep 2018

https://life.ru/t/%D0%BD%D0%BE%D0%B2%D0%BE%D1%81%D1%82%D0%B8/1154212/uchionyie_iz_britanii_nashli_akhilliesovu_piatu_virusa_ghrippa

© 2019 Blue Water Vaccines, Inc.